Chaste Commit::ca8ccdedf819b6e02855bc0e8e6f50bdecbc5208
ContactInhibitionCellCycleModel.cpp
1/*
2
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34*/
35
36#include "ContactInhibitionCellCycleModel.hpp"
37#include "CellLabel.hpp"
38#include "DifferentiatedCellProliferativeType.hpp"
39
42 mQuiescentVolumeFraction(DOUBLE_UNSET),
43 mEquilibriumVolume(DOUBLE_UNSET),
44 mCurrentQuiescentOnsetTime(SimulationTime::Instance()->GetTime()),
45 mCurrentQuiescentDuration(0.0)
46{
47}
48
51 mQuiescentVolumeFraction(rModel.mQuiescentVolumeFraction),
52 mEquilibriumVolume(rModel.mEquilibriumVolume),
53 mCurrentQuiescentOnsetTime(rModel.mCurrentQuiescentOnsetTime),
54 mCurrentQuiescentDuration(rModel.mCurrentQuiescentDuration)
55{
56 /*
57 * Initialize only those member variables defined in this class.
58 *
59 * The member variables mCurrentCellCyclePhase, mG1Duration,
60 * mMinimumGapDuration, mStemCellG1Duration, mTransitCellG1Duration,
61 * mSDuration, mG2Duration and mMDuration are initialized in the
62 * AbstractPhaseBasedCellCycleModel constructor.
63 *
64 * The member variables mBirthTime, mReadyToDivide and mDimension
65 * are initialized in the AbstractCellCycleModel constructor.
66 *
67 * Note that mG1Duration is (re)set as soon as InitialiseDaughterCell()
68 * is called on the new cell-cycle model.
69 */
70}
71
73{
75 {
76 EXCEPTION("The member variables mQuiescentVolumeFraction and mEquilibriumVolume have not yet been set.");
77 }
78
79 // Get cell volume
80 double cell_volume = mpCell->GetCellData()->GetItem("volume");
81
82 // Removes the cell label
83 mpCell->RemoveCellProperty<CellLabel>();
84
85 if (mCurrentCellCyclePhase == G_ONE_PHASE)
86 {
87 // Update G1 duration based on cell volume
89 double quiescent_volume = mEquilibriumVolume * mQuiescentVolumeFraction;
90
91 if (cell_volume < quiescent_volume)
92 {
93 // Update the duration of the current period of contact inhibition.
95 mG1Duration += dt;
96
97 /*
98 * This method is usually called within a CellBasedSimulation, after the CellPopulation
99 * has called CellPropertyRegistry::TakeOwnership(). This means that were we to call
100 * CellPropertyRegistry::Instance() here when adding the CellLabel, we would be creating
101 * a new CellPropertyRegistry. In this case the CellLabel's cell count would be incorrect.
102 * We must therefore access the CellLabel via the cell's CellPropertyCollection.
103 */
104 boost::shared_ptr<AbstractCellProperty> p_label =
105 mpCell->rGetCellPropertyCollection().GetCellPropertyRegistry()->Get<CellLabel>();
106 mpCell->AddCellProperty(p_label);
107 }
108 else
109 {
110 // Reset the cell's quiescent duration and update the time at which the onset of quiescent occurs
113 }
114 }
115
116 double time_since_birth = GetAge();
117 assert(time_since_birth >= 0);
118
119 if (mpCell->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>())
120 {
121 mCurrentCellCyclePhase = G_ZERO_PHASE;
122 }
123 else if (time_since_birth < GetMDuration())
124 {
125 mCurrentCellCyclePhase = M_PHASE;
126 }
127 else if (time_since_birth < GetMDuration() + mG1Duration)
128 {
129 mCurrentCellCyclePhase = G_ONE_PHASE;
130 }
131 else if (time_since_birth < GetMDuration() + mG1Duration + GetSDuration())
132 {
133 mCurrentCellCyclePhase = S_PHASE;
134 }
135 else if (time_since_birth < GetMDuration() + mG1Duration + GetSDuration() + GetG2Duration())
136 {
137 mCurrentCellCyclePhase = G_TWO_PHASE;
138 }
139}
140
145
147{
148 mQuiescentVolumeFraction = quiescentVolumeFraction;
149}
150
155
157{
158 mEquilibriumVolume = equilibriumVolume;
159}
160
165
170
175
177{
178 *rParamsFile << "\t\t\t<QuiescentVolumeFraction>" << mQuiescentVolumeFraction << "</QuiescentVolumeFraction>\n";
179 *rParamsFile << "\t\t\t<EquilibriumVolume>" << mEquilibriumVolume << "</EquilibriumVolume>\n";
180
181 // Call method on direct parent class
183}
184
185// Serialization for Boost >= 1.36
const double DOUBLE_UNSET
Definition Exception.hpp:57
#define EXCEPTION(message)
#define CHASTE_CLASS_EXPORT(T)
virtual void OutputCellCycleModelParameters(out_stream &rParamsFile)
virtual void OutputCellCycleModelParameters(out_stream &rParamsFile)
void SetEquilibriumVolume(double equilibriumVolume)
void SetQuiescentVolumeFraction(double quiescentVolumeFraction)
double GetTime() const
double GetTimeStep() const
static SimulationTime * Instance()