Chaste Commit::ca8ccdedf819b6e02855bc0e8e6f50bdecbc5208
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#include <UniformG1GenerationalCellCycleModel.hpp>
Protected Member Functions | |
void | SetG1Duration () |
UniformG1GenerationalCellCycleModel (const UniformG1GenerationalCellCycleModel &rModel) | |
Protected Member Functions inherited from AbstractSimpleGenerationalCellCycleModel | |
AbstractSimpleGenerationalCellCycleModel (const AbstractSimpleGenerationalCellCycleModel &rModel) | |
Protected Member Functions inherited from AbstractSimplePhaseBasedCellCycleModel | |
AbstractSimplePhaseBasedCellCycleModel (const AbstractSimplePhaseBasedCellCycleModel &rModel) | |
Protected Member Functions inherited from AbstractPhaseBasedCellCycleModel | |
AbstractPhaseBasedCellCycleModel (const AbstractPhaseBasedCellCycleModel &rModel) | |
Protected Member Functions inherited from AbstractCellCycleModel | |
AbstractCellCycleModel (const AbstractCellCycleModel &rModel) | |
Private Member Functions | |
template<class Archive > | |
void | serialize (Archive &archive, const unsigned int version) |
Friends | |
class | TestSimpleCellCycleModels |
class | boost::serialization::access |
Additional Inherited Members | |
Protected Attributes inherited from AbstractSimpleGenerationalCellCycleModel | |
unsigned | mGeneration |
unsigned | mMaxTransitGenerations |
Protected Attributes inherited from AbstractPhaseBasedCellCycleModel | |
CellCyclePhase | mCurrentCellCyclePhase |
double | mG1Duration |
double | mMinimumGapDuration |
double | mStemCellG1Duration |
double | mTransitCellG1Duration |
double | mSDuration |
double | mG2Duration |
double | mMDuration |
Protected Attributes inherited from AbstractCellCycleModel | |
CellPtr | mpCell |
double | mBirthTime |
bool | mReadyToDivide |
unsigned | mDimension |
A stochastic cell-cycle model employed by Meineke et al (2001) in their off-lattice model of the intestinal crypt (doi:10.1046/j.0960-7722.2001.00216.x). Cells that are proliferating are assigned G1 phase durations drawn from a uniform distribution, which differs between stem and transit amplifying cells. All other cell-cycle phases are held constant.
Definition at line 49 of file UniformG1GenerationalCellCycleModel.hpp.
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protected |
Protected copy-constructor for use by CreateCellCycleModel().
The only way for external code to create a copy of a cell-cycle model is by calling that method, to ensure that a model of the correct subclass is created. This copy-constructor helps subclasses to ensure that all member variables are correctly copied when this happens.
This method is called by child classes to set member variables for a daughter cell upon cell division. Note that the parent cell cycle model will have had ResetForDivision() called just before CreateCellCycleModel() is called, so performing an exact copy of the parent is suitable behaviour. Any daughter-cell-specific initialisation can be done in InitialiseDaughterCell().
rModel | the cell cycle model to copy. |
Definition at line 45 of file UniformG1GenerationalCellCycleModel.cpp.
UniformG1GenerationalCellCycleModel::UniformG1GenerationalCellCycleModel | ( | ) |
Constructor - just a default, mBirthTime is set in the AbstractCellCycleModel class. mG1Duration is set very high, it is set for the individual cells when InitialiseDaughterCell is called
Definition at line 41 of file UniformG1GenerationalCellCycleModel.cpp.
Referenced by CreateCellCycleModel().
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virtual |
Overridden builder method to create new copies of this cell-cycle model.
Implements AbstractCellCycleModel.
Definition at line 66 of file UniformG1GenerationalCellCycleModel.cpp.
References UniformG1GenerationalCellCycleModel().
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virtual |
Overridden OutputCellCycleModelParameters() method.
rParamsFile | the file stream to which the parameters are output |
Reimplemented from AbstractSimpleGenerationalCellCycleModel.
Definition at line 95 of file UniformG1GenerationalCellCycleModel.cpp.
References AbstractSimpleGenerationalCellCycleModel::OutputCellCycleModelParameters().
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inlineprivate |
Archive the cell-cycle model and random number generator, never used directly - boost uses this.
archive | the archive |
version | the current version of this class |
Definition at line 64 of file UniformG1GenerationalCellCycleModel.hpp.
References SerializableSingleton< SINGLETON_CLASS >::GetSerializationWrapper(), and RandomNumberGenerator::Instance().
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protectedvirtual |
Set the duration of G1 phase. This method is called on each cell at the start of a simulation, and for both daughter cells immediately following cell division.
If the cell associated with this cell-cycle model has stem proliferative type, then the G1 phase duration is drawn from the uniform distribution U[14,18]. If the cell has transit proliferative type (semi-differentiated), then the G1 phase duration is drawn from the uniform distribution U[4,6]. These two distributions, proposed by Meineke et al (doi:10.1046/j.0960-7722.2001.00216.x), reflect indirect biological observations that stem cells cycle more slowly than their progeny.
If the cell is differentiated, then the G1 phase duration is set to DBL_MAX, so that the cell will never reach the end of G1 phase.
Reimplemented from AbstractSimplePhaseBasedCellCycleModel.
Definition at line 71 of file UniformG1GenerationalCellCycleModel.cpp.
References AbstractPhaseBasedCellCycleModel::GetStemCellG1Duration(), AbstractPhaseBasedCellCycleModel::GetTransitCellG1Duration(), RandomNumberGenerator::Instance(), AbstractPhaseBasedCellCycleModel::mG1Duration, AbstractCellCycleModel::mpCell, NEVER_REACHED, and RandomNumberGenerator::ranf().
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friend |
Needed for serialization.
Definition at line 56 of file UniformG1GenerationalCellCycleModel.hpp.
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friend |
Definition at line 51 of file UniformG1GenerationalCellCycleModel.hpp.