AbstractVanLeeuwen2009WntSwatCellCycleModel.hpp

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*/
 
#ifndef ABSTRACTVANLEEUWEN2009WNTSWATCELLCYCLEMODEL_HPP_
#define ABSTRACTVANLEEUWEN2009WNTSWATCELLCYCLEMODEL_HPP_
 
#include "ChasteSerialization.hpp"
#include "ClassIsAbstract.hpp"
#include <boost/serialization/base_object.hpp>
 
#include <cfloat>
 
#include "AbstractOdeSystem.hpp"
#include "AbstractWntOdeBasedCellCycleModel.hpp"
#include "VanLeeuwen2009WntSwatCellCycleOdeSystem.hpp"
#include "AbstractCellMutationState.hpp"
 
class AbstractVanLeeuwen2009WntSwatCellCycleModel : public AbstractWntOdeBasedCellCycleModel
{
private:
 
    friend class boost::serialization::access;
    template<class Archive>
    void serialize(Archive & archive, const unsigned int version)
    {
        archive & boost::serialization::base_object<AbstractWntOdeBasedCellCycleModel>(*this);
    }
 
    void ChangeCellProliferativeTypeDueToCurrentBetaCateninLevel();
 
    void AdjustOdeParameters(double currentTime);
 
protected:
 
    AbstractVanLeeuwen2009WntSwatCellCycleModel(const AbstractVanLeeuwen2009WntSwatCellCycleModel& rModel);
 
public:
 
    AbstractVanLeeuwen2009WntSwatCellCycleModel(boost::shared_ptr<AbstractCellCycleModelOdeSolver> pOdeSolver = boost::shared_ptr<AbstractCellCycleModelOdeSolver>());
 
    void Initialise();
 
    double GetMembraneBoundBetaCateninLevel();
 
    double GetCytoplasmicBetaCateninLevel();
 
    double GetNuclearBetaCateninLevel();
 
    virtual void InitialiseOdeSystem(double wntConcentration, boost::shared_ptr<AbstractCellMutationState> pMutationState)=0;
 
    virtual void OutputCellCycleModelParameters(out_stream& rParamsFile);
};
 
CLASS_IS_ABSTRACT(AbstractVanLeeuwen2009WntSwatCellCycleModel)
 
#endif /*ABSTRACTVANLEEUWEN2009WNTSWATCELLCYCLEMODEL_HPP_*/