Chaste Commit::baa90ac2819b962188b7562f2326be23c47859a7
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#include <AbstractRushLarsenCardiacCell.hpp>
Public Member Functions | |
AbstractRushLarsenCardiacCell (unsigned numberOfStateVariables, unsigned voltageIndex, boost::shared_ptr< AbstractStimulusFunction > pIntracellularStimulus) | |
virtual | ~AbstractRushLarsenCardiacCell () |
OdeSolution | Compute (double tStart, double tEnd, double tSamp=0.0) |
void | ComputeExceptVoltage (double tStart, double tEnd) |
void | SolveAndUpdateState (double tStart, double tEnd) |
Public Member Functions inherited from AbstractCardiacCell | |
AbstractCardiacCell (boost::shared_ptr< AbstractIvpOdeSolver > pOdeSolver, unsigned numberOfStateVariables, unsigned voltageIndex, boost::shared_ptr< AbstractStimulusFunction > pIntracellularStimulus) | |
virtual | ~AbstractCardiacCell () |
void | Init () |
void | SetTimestep (double dt) |
void | SetVoltage (double voltage) |
double | GetVoltage () |
unsigned | GetNumberOfStateVariables () const |
unsigned | GetNumberOfParameters () const |
std::vector< double > | GetStdVecStateVariables () |
const std::vector< std::string > & | rGetStateVariableNames () const |
void | SetStateVariables (const std::vector< double > &rVariables) |
void | SetStateVariable (unsigned index, double newValue) |
void | SetStateVariable (const std::string &rName, double newValue) |
double | GetAnyVariable (const std::string &rName, double time=0.0) |
double | GetParameter (const std::string &rParameterName) |
double | GetParameter (unsigned parameterIndex) |
void | SetParameter (const std::string &rParameterName, double value) |
virtual void | SetState (CellModelState state) |
virtual void | SetSlowValues (const std::vector< double > &rSlowValues) |
virtual void | GetSlowValues (std::vector< double > &rSlowValues) |
virtual bool | IsFastOnly () |
virtual void | AdjustOutOfRangeSlowValues (std::vector< double > &rSlowValues) |
virtual unsigned | GetNumSlowValues () |
Public Member Functions inherited from AbstractCardiacCellInterface | |
AbstractCardiacCellInterface (boost::shared_ptr< AbstractIvpOdeSolver > pOdeSolver, unsigned voltageIndex, boost::shared_ptr< AbstractStimulusFunction > pIntracellularStimulus) | |
virtual | ~AbstractCardiacCellInterface () |
virtual double | GetIIonic (const std::vector< double > *pStateVariables=NULL)=0 |
unsigned | GetVoltageIndex () |
void | SetStimulusFunction (boost::shared_ptr< AbstractStimulusFunction > pStimulus) |
double | GetStimulus (double time) |
void | SetIntracellularStimulusFunction (boost::shared_ptr< AbstractStimulusFunction > pStimulus) |
double | GetIntracellularStimulus (double time) |
double | GetIntracellularAreaStimulus (double time) |
void | SetUsedInTissueSimulation (bool tissue=true) |
virtual boost::shared_ptr< RegularStimulus > | UseCellMLDefaultStimulus () |
bool | HasCellMLDefaultStimulus () |
virtual AbstractLookupTableCollection * | GetLookupTableCollection () |
boost::shared_ptr< AbstractStimulusFunction > | GetStimulusFunction () |
const boost::shared_ptr< AbstractStimulusFunction > | GetStimulusFunction () const |
const boost::shared_ptr< AbstractIvpOdeSolver > | GetSolver () const |
void | SetSolver (boost::shared_ptr< AbstractIvpOdeSolver > pSolver) |
virtual void | SetVoltageDerivativeToZero (bool clamp=true) |
void | SetFixedVoltage (double voltage) |
virtual void | SetStretch (double stretch) |
virtual double | GetIntracellularCalciumConcentration () |
Public Member Functions inherited from AbstractOdeSystem | |
AbstractOdeSystem (unsigned numberOfStateVariables) | |
virtual | ~AbstractOdeSystem () |
virtual bool | CalculateStoppingEvent (double time, const std::vector< double > &rY) |
virtual double | CalculateRootFunction (double time, const std::vector< double > &rY) |
bool | GetUseAnalyticJacobian () |
const std::vector< double > & | rGetConstStateVariables () const |
Public Member Functions inherited from AbstractParameterisedSystem< std::vector< double > > | |
AbstractParameterisedSystem (unsigned numberOfStateVariables) | |
std::vector< double > & | rGetStateVariables () |
std::vector< double > | GetStateVariables () |
void | SetStateVariables (const std::vector< double > &rStateVariables) |
double | GetStateVariable (unsigned index) const |
double | GetStateVariable (const std::string &rName) const |
void | SetStateVariable (unsigned index, double newValue) |
void | SetStateVariable (const std::string &rName, double newValue) |
virtual void | VerifyStateVariables () |
void | SetDefaultInitialConditions (const std::vector< double > &rInitialConditions) |
void | SetDefaultInitialCondition (unsigned index, double initialCondition) |
std::vector< double > | GetInitialConditions () const |
void | ResetToInitialConditions () |
double | GetParameter (unsigned index) const |
double | GetParameter (const std::string &rName) const |
void | SetParameter (const std::string &rName, double value) |
void | SetParameter (unsigned index, double value) |
double | GetAnyVariable (unsigned index, double time=0.0, std::vector< double > *pDerivedQuantities=NULL) |
double | GetAnyVariable (const std::string &rName, double time=0.0, std::vector< double > *pDerivedQuantities=NULL) |
void | SetAnyVariable (unsigned index, double value) |
void | SetAnyVariable (const std::string &rName, double value) |
virtual std::vector< double > | ComputeDerivedQuantities (double time, const std::vector< double > &rState) |
std::vector< double > | ComputeDerivedQuantitiesFromCurrentState (double time) |
Public Member Functions inherited from AbstractUntemplatedParameterisedSystem | |
AbstractUntemplatedParameterisedSystem (unsigned numberOfStateVariables) | |
virtual | ~AbstractUntemplatedParameterisedSystem () |
boost::shared_ptr< const AbstractOdeSystemInformation > | GetSystemInformation () const |
std::string | GetSystemName () const |
unsigned | GetNumberOfAttributes () const |
bool | HasAttribute (const std::string &rName) const |
double | GetAttribute (const std::string &rName) const |
unsigned | GetNumberOfStateVariables () const |
const std::vector< std::string > & | rGetStateVariableNames () const |
const std::vector< std::string > & | rGetStateVariableUnits () const |
unsigned | GetStateVariableIndex (const std::string &rName) const |
bool | HasStateVariable (const std::string &rName) const |
std::string | GetStateVariableUnits (unsigned index) const |
unsigned | GetNumberOfParameters () const |
const std::vector< std::string > & | rGetParameterNames () const |
const std::vector< std::string > & | rGetParameterUnits () const |
unsigned | GetParameterIndex (const std::string &rName) const |
bool | HasParameter (const std::string &rName) const |
std::string | GetParameterUnits (unsigned index) const |
unsigned | GetNumberOfDerivedQuantities () const |
const std::vector< std::string > & | rGetDerivedQuantityNames () const |
const std::vector< std::string > & | rGetDerivedQuantityUnits () const |
unsigned | GetDerivedQuantityIndex (const std::string &rName) const |
bool | HasDerivedQuantity (const std::string &rName) const |
std::string | GetDerivedQuantityUnits (unsigned index) const |
unsigned | GetAnyVariableIndex (const std::string &rName) const |
bool | HasAnyVariable (const std::string &rName) const |
std::string | GetAnyVariableUnits (unsigned index) const |
std::string | GetAnyVariableUnits (const std::string &rName) const |
Protected Member Functions | |
virtual void | ComputeOneStepExceptVoltage (const std::vector< double > &rDY, const std::vector< double > &rAlphaOrTau, const std::vector< double > &rBetaOrInf)=0 |
void | UpdateTransmembranePotential (const std::vector< double > &rDY) |
virtual void | EvaluateEquations (double time, std::vector< double > &rDY, std::vector< double > &rAlphaOrTau, std::vector< double > &rBetaOrInf)=0 |
Protected Member Functions inherited from AbstractParameterisedSystem< std::vector< double > > | |
std::string | DumpState (const std::string &rMessage) |
std::string | DumpState (const std::string &rMessage, std::vector< double > Y) |
std::string | DumpState (const std::string &rMessage, std::vector< double > Y, double time) |
void | CheckParametersOnLoad (const std::vector< double > &rParameters, const std::vector< std::string > &rParameterNames) |
Private Member Functions | |
template<class Archive > | |
void | serialize (Archive &archive, const unsigned int version) |
void | EvaluateYDerivatives (double time, const std::vector< double > &rY, std::vector< double > &rDY) |
Friends | |
class | boost::serialization::access |
Additional Inherited Members | |
Protected Attributes inherited from AbstractCardiacCell | |
double | mDt |
Protected Attributes inherited from AbstractCardiacCellInterface | |
unsigned | mVoltageIndex |
boost::shared_ptr< AbstractIvpOdeSolver > | mpOdeSolver |
boost::shared_ptr< AbstractStimulusFunction > | mpIntracellularStimulus |
bool | mSetVoltageDerivativeToZero |
bool | mIsUsedInTissue |
bool | mHasDefaultStimulusFromCellML |
double | mFixedVoltage |
Protected Attributes inherited from AbstractOdeSystem | |
bool | mUseAnalyticJacobian |
Protected Attributes inherited from AbstractParameterisedSystem< std::vector< double > > | |
std::vector< double > | mStateVariables |
std::vector< double > | mParameters |
Protected Attributes inherited from AbstractUntemplatedParameterisedSystem | |
unsigned | mNumberOfStateVariables |
boost::shared_ptr< AbstractOdeSystemInformation > | mpSystemInfo |
This is the base class for cardiac cells solved using the Rush-Larsen method. It is based on code contributed by Megan Lewis, University of Saskatchewan
The basic approach to solving such models is:
Definition at line 58 of file AbstractRushLarsenCardiacCell.hpp.
AbstractRushLarsenCardiacCell::AbstractRushLarsenCardiacCell | ( | unsigned | numberOfStateVariables, |
unsigned | voltageIndex, | ||
boost::shared_ptr< AbstractStimulusFunction > | pIntracellularStimulus | ||
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Standard constructor for a cell.
numberOfStateVariables | the size of the ODE system |
voltageIndex | the index of the variable representing the transmembrane potential within the state variable vector |
pIntracellularStimulus | the intracellular stimulus function |
Some notes for future reference:
Definition at line 45 of file AbstractRushLarsenCardiacCell.cpp.
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virtual |
Virtual destructor
Definition at line 54 of file AbstractRushLarsenCardiacCell.cpp.
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virtual |
Simulates this cell's behaviour between the time interval [tStart, tEnd], with timestep mDt. Uses a forward Euler step to update the transmembrane potential at each timestep.
The length of the time interval must be a multiple of the timestep.
tStart | beginning of the time interval to simulate |
tEnd | end of the time interval to simulate |
tSamp | sampling interval for returned results (defaults to mDt) |
Reimplemented from AbstractCardiacCell.
Definition at line 57 of file AbstractRushLarsenCardiacCell.cpp.
References ComputeOneStepExceptVoltage(), EvaluateEquations(), AbstractCardiacCell::mDt, AbstractUntemplatedParameterisedSystem::mNumberOfStateVariables, AbstractUntemplatedParameterisedSystem::mpSystemInfo, OdeSolution::rGetSolutions(), AbstractParameterisedSystem< std::vector< double > >::rGetStateVariables(), OdeSolution::rGetTimes(), OdeSolution::SetNumberOfTimeSteps(), OdeSolution::SetOdeSystemInformation(), UpdateTransmembranePotential(), and AbstractParameterisedSystem< std::vector< double > >::VerifyStateVariables().
Simulates this cell's behaviour between the time interval [tStart, tEnd], with timestep mDt. The transmembrane potential is kept fixed throughout, but the other state variables are updated.
The length of the time interval must be a multiple of the timestep.
tStart | beginning of the time interval to simulate |
tEnd | end of the time interval to simulate |
Reimplemented from AbstractCardiacCell.
Definition at line 106 of file AbstractRushLarsenCardiacCell.cpp.
References TimeStepper::AdvanceOneTimeStep(), ComputeOneStepExceptVoltage(), EvaluateEquations(), TimeStepper::GetTime(), TimeStepper::IsTimeAtEnd(), AbstractCardiacCell::mDt, AbstractUntemplatedParameterisedSystem::mNumberOfStateVariables, AbstractCardiacCellInterface::mSetVoltageDerivativeToZero, and AbstractParameterisedSystem< std::vector< double > >::VerifyStateVariables().
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protectedpure virtual |
Update the values of elligible gating variables using the Rush-Larsen method, and of other non-V variables using forward Euler, for a single timestep.
rDY | vector containing dy/dt values |
rAlphaOrTau | vector containing alpha or tau values, depending on the formulation |
rBetaOrInf | vector containing beta or inf values, depending on the formulation |
Referenced by Compute(), ComputeExceptVoltage(), and SolveAndUpdateState().
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protectedpure virtual |
Compute dy/dt and alpha and beta values.
time | start of this timestep |
rDY | vector to fill in with dy/dt values |
rAlphaOrTau | vector to fill in with alpha or tau values, depending on the formulation |
rBetaOrInf | vector to fill in with beta or inf values, depending on the formulation |
Referenced by Compute(), ComputeExceptVoltage(), and SolveAndUpdateState().
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inlineprivatevirtual |
This function should never be called - the cell class incorporates its own solver.
time | |
rY | |
rDY |
Implements AbstractOdeSystem.
Definition at line 142 of file AbstractRushLarsenCardiacCell.hpp.
References NEVER_REACHED.
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inlineprivate |
Archive the member variables.
archive | |
version |
Definition at line 70 of file AbstractRushLarsenCardiacCell.hpp.
Simulate this cell's behaviour between the time interval [tStart, tEnd], with timestemp mDt, updating the internal state variable values.
tStart | beginning of the time interval to simulate |
tEnd | end of the time interval to simulate |
Reimplemented from AbstractCardiacCell.
Definition at line 130 of file AbstractRushLarsenCardiacCell.cpp.
References TimeStepper::AdvanceOneTimeStep(), ComputeOneStepExceptVoltage(), EvaluateEquations(), TimeStepper::GetTime(), TimeStepper::IsTimeAtEnd(), AbstractCardiacCell::mDt, AbstractUntemplatedParameterisedSystem::mNumberOfStateVariables, UpdateTransmembranePotential(), and AbstractParameterisedSystem< std::vector< double > >::VerifyStateVariables().
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protected |
Perform a forward Euler step to update the transmembrane potential.
rDY | vector containing dy/dt values |
Definition at line 149 of file AbstractRushLarsenCardiacCell.cpp.
References AbstractCardiacCellInterface::GetVoltageIndex(), AbstractCardiacCell::mDt, and AbstractParameterisedSystem< std::vector< double > >::rGetStateVariables().
Referenced by Compute(), and SolveAndUpdateState().
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friend |
Needed for serialization.
Definition at line 62 of file AbstractRushLarsenCardiacCell.hpp.