Chaste Commit::ca8ccdedf819b6e02855bc0e8e6f50bdecbc5208
ExtendedBidomainProblem.cpp
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35
36
37#include "ExtendedBidomainProblem.hpp"
38#include "ExtendedBidomainSolver.hpp"
39#include "AbstractDynamicLinearPdeSolver.hpp"
40#include "HeartConfig.hpp"
41#include "Exception.hpp"
42#include "DistributedVector.hpp"
43#include "ReplicatableVector.hpp"
44
45template<unsigned DIM>
47 AbstractCardiacCellFactory<DIM>* pCellFactory, AbstractCardiacCellFactory<DIM>* pSecondCellFactory, bool hasBath)
48 : AbstractCardiacProblem<DIM,DIM, 3>(pCellFactory),
49 mpSecondCellFactory(pSecondCellFactory),
50 mpExtendedBidomainTissue(NULL),
51 mUserSpecifiedSecondCellConductivities(false),
52 mUserHasSetBidomainValuesExplicitly(false),
53 mpExtracellularStimulusFactory(NULL),
54 mRowForAverageOfPhiZeroed(INT_MAX),
55 mApplyAveragePhieZeroConstraintAfterSolving(false),
56 mUserSuppliedExtracellularStimulus(false),
57 mHasBath(hasBath)
58{
60}
61
62template<unsigned DIM>
64 : AbstractCardiacProblem<DIM,DIM, 3>(),
65 mpSecondCellFactory(NULL),
66 mpExtendedBidomainTissue(NULL),
67 mUserSpecifiedSecondCellConductivities(false),
68 mUserHasSetBidomainValuesExplicitly(false),
69 mpExtracellularStimulusFactory(NULL),
70 mRowForAverageOfPhiZeroed(INT_MAX),
71 mApplyAveragePhieZeroConstraintAfterSolving(false),
72 mUserSuppliedExtracellularStimulus(false)
73{
75}
76
77template<unsigned DIM>
79{
80
81 DistributedVectorFactory* p_factory = this->mpMesh->GetDistributedVectorFactory();
82 Vec initial_condition = p_factory->CreateVec(3);
83 DistributedVector ic = p_factory->CreateDistributedVector(initial_condition);
84 std::vector<DistributedVector::Stripe> stripe;
85 stripe.reserve(3);
86
87 stripe.push_back(DistributedVector::Stripe(ic, 0));
88 stripe.push_back(DistributedVector::Stripe(ic, 1));
89 stripe.push_back(DistributedVector::Stripe(ic, 2));
90
91 for (DistributedVector::Iterator index = ic.Begin();
92 index != ic.End();
93 ++index)
94 {
95 stripe[0][index] = mpExtendedBidomainTissue->GetCardiacCell(index.Global)->GetVoltage();//phi_i of frrst cell = Vm first cell at the start
96 stripe[1][index] = mpExtendedBidomainTissue->GetCardiacSecondCell(index.Global)->GetVoltage();//phi_i of second cell = Vm second cell at the start
97 stripe[2][index] = 0.0;//
98 }
99 ic.Restore();
100
101 return initial_condition;
102}
103
104template<unsigned DIM>
106{
107 if (mpExtracellularStimulusFactory == NULL) // user has not passed in any extracellular stimulus in any form
108 {
109 mpExtracellularStimulusFactory = new AbstractStimulusFactory<DIM>();
110 // Create one (with default implementation to zero stimulus everywhere)
111 }
112
113 assert(mpExtracellularStimulusFactory); // should be created by now, either above or by the user...
114 mpExtracellularStimulusFactory->SetMesh(this->mpMesh);//so, set the mesh into it.
115 mpExtracellularStimulusFactory->SetCompatibleExtracellularStimulus();//make sure compatibility condition will be valid
116
117 std::vector<AbstractChasteRegion<DIM>* > grounded_regions = mpExtracellularStimulusFactory->GetRegionsToBeGrounded();
118
119 if ((mUserSuppliedExtracellularStimulus) && grounded_regions.size() > 0) //we check for grunded nodes here
120 {
121 std::vector<unsigned> grounded_indices;
122 for (unsigned global_node_index = 0; global_node_index < this->mpMesh->GetNumNodes(); global_node_index++)
123 {
124 if (this->mpMesh->GetDistributedVectorFactory()->IsGlobalIndexLocal(global_node_index))
125 {
126 for (unsigned region_index = 0; region_index <grounded_regions.size(); region_index++)
127 {
128 if (grounded_regions[region_index]->DoesContain(this->mpMesh->GetNode(global_node_index)->GetPoint()))
129 {
130 grounded_indices.push_back( this->mpMesh->GetNode(global_node_index)->GetIndex() );
131 }
132 }
133 }
134 }
136 SetFixedExtracellularPotentialNodes(grounded_indices);
137 }
138}
139
140template<unsigned DIM>
142{
143 //set the mesh into the second cell factory as well.
144 mpSecondCellFactory->SetMesh(this->mpMesh);
145
146 //deal with extracellular stimulus, if any
147 ProcessExtracellularStimulus();
148
149 //Now create the tissue object
150 mpExtendedBidomainTissue = new ExtendedBidomainTissue<DIM>(this->mpCellFactory, mpSecondCellFactory,mpExtracellularStimulusFactory);
151
152 //Let the Tissue know if the user wants an extracellular stimulus (or if we had to create a default zero one).
153 mpExtendedBidomainTissue->SetUserSuppliedExtracellularStimulus(mUserSuppliedExtracellularStimulus);
154
155 //if the user remembered to set a different value for the sigma of the second cell...
156 if (mUserSpecifiedSecondCellConductivities)
157 {
158 mpExtendedBidomainTissue->SetIntracellularConductivitiesSecondCell(mIntracellularConductivitiesSecondCell);
159 }
160 else //..otherwise it gets the same as the first cell (according to heartconfig...)
161 {
162 c_vector<double, DIM> intra_conductivities;
164 mpExtendedBidomainTissue->SetIntracellularConductivitiesSecondCell(intra_conductivities);
165 }
166
167 //the conductivities for the first cell are created within the tissue constructor in the abstract class
168 //here we create the ones for the second cell
169 mpExtendedBidomainTissue->CreateIntracellularConductivityTensorSecondCell();
170
171 if (mUserHasSetBidomainValuesExplicitly)
172 {
173 mpExtendedBidomainTissue->SetAmFirstCell(mAmFirstCell);
174 mpExtendedBidomainTissue->SetAmSecondCell(mAmSecondCell);
175 mpExtendedBidomainTissue->SetAmGap(mAmGap);
176 mpExtendedBidomainTissue->SetGGap(mGGap);
177 mpExtendedBidomainTissue->SetCmFirstCell(mCmFirstCell);
178 mpExtendedBidomainTissue->SetCmSecondCell(mCmSecondCell);
179 }
180 else//we set all the Am and Cm to the values set by the heartconfig (only one value for all Am and one value for all Cms)
181 {
182 mpExtendedBidomainTissue->SetAmFirstCell(HeartConfig::Instance()->GetSurfaceAreaToVolumeRatio());
183 mpExtendedBidomainTissue->SetAmSecondCell(HeartConfig::Instance()->GetSurfaceAreaToVolumeRatio());
184 mpExtendedBidomainTissue->SetAmGap(HeartConfig::Instance()->GetSurfaceAreaToVolumeRatio());
185 mpExtendedBidomainTissue->SetGGap(0.0);
186 mpExtendedBidomainTissue->SetCmFirstCell(HeartConfig::Instance()->GetCapacitance());
187 mpExtendedBidomainTissue->SetCmSecondCell(HeartConfig::Instance()->GetCapacitance());
188 }
189
190 mpExtendedBidomainTissue->SetGgapHeterogeneities(mGgapHeterogeneityRegions, mGgapHeterogenousValues);//set user input into the tissue class
191 mpExtendedBidomainTissue->CreateGGapConductivities();//if vectors are empty, mGgap will be put everywhere by this method.
192
193 return mpExtendedBidomainTissue;
194}
195
196template<unsigned DIM>
197void ExtendedBidomainProblem<DIM>::SetExtendedBidomainParameters(double Am1, double Am2, double AmGap, double Cm1, double Cm2, double Ggap)
198{
199 mAmFirstCell = Am1;
200 mAmSecondCell = Am2;
201 mAmGap = AmGap;
202 mCmFirstCell = Cm1;
203 mCmSecondCell = Cm2;
204 mGGap = Ggap;
205
206 mUserHasSetBidomainValuesExplicitly = true;
207}
208
209template <unsigned DIM>
210void ExtendedBidomainProblem<DIM>::SetGgapHeterogeneities ( std::vector<boost::shared_ptr<AbstractChasteRegion<DIM> > >& rGgapHeterogeneityRegions, std::vector<double>& rGgapValues)
211{
212 if (rGgapHeterogeneityRegions.size() != rGgapValues.size() )
213 {
214 EXCEPTION ("Gap junction heterogeneity areas must be of the same number as the heterogeneity values");
215 }
216 mGgapHeterogeneityRegions = rGgapHeterogeneityRegions;
217 mGgapHeterogenousValues =rGgapValues;
218}
219
220template <unsigned DIM>
222{
223 mpExtracellularStimulusFactory = pFactory;
224 mUserSuppliedExtracellularStimulus = true;
225}
226
227template<unsigned DIM>
229{
230 /*
231 * NOTE: The this->mpBoundaryConditionsContainer.get() lines below convert a
232 * boost::shared_ptr to a normal pointer, as this is what the assemblers are
233 * expecting. We have to be a bit careful though as boost could decide to delete
234 * them whenever it feels like as it won't count the assemblers as using them.
235 *
236 * As long as they are kept as member variables here for as long as they are
237 * required in the assemblers it should all work OK.
238 */
239
240 mpSolver = new ExtendedBidomainSolver<DIM,DIM>( mHasBath,
241 this->mpMesh,
242 mpExtendedBidomainTissue,
243 this->mpBoundaryConditionsContainer.get());
244
245 try
246 {
247 mpSolver->SetFixedExtracellularPotentialNodes(mFixedExtracellularPotentialNodes);
248 mpSolver->SetRowForAverageOfPhiZeroed(mRowForAverageOfPhiZeroed);
249 }
250 catch (const Exception& e)
251 {
252 delete mpSolver;
253 throw e;
254 }
255
256 return mpSolver;
257}
258
259template<unsigned DIM>
261{
262 if (!mUserSuppliedExtracellularStimulus)
263 {
264 delete mpExtracellularStimulusFactory;
265 }
266}
267
268template<unsigned DIM>
270{
271 for (unsigned i = 0; i < DIM; i++)
272 {
273 mIntracellularConductivitiesSecondCell[i] = conductivities[i];
274 }
275 mUserSpecifiedSecondCellConductivities = true;
276}
277
278template<unsigned DIM>
280{
281 assert(mFixedExtracellularPotentialNodes.size() == 0);
282 mFixedExtracellularPotentialNodes.resize(nodes.size());
283 for (unsigned i=0; i<nodes.size(); i++)
284 {
285 // the assembler checks that the nodes[i] is less than
286 // the number of nodes in the mesh so this is not done here
287 mFixedExtracellularPotentialNodes[i] = nodes[i];
288 }
289}
290
291template<unsigned DIM>
293{
294 if (node==0)
295 {
296 mRowForAverageOfPhiZeroed = 2;
297 }
298 else
299 {
300 //Phie is every three lines, starting from zero...
301 mRowForAverageOfPhiZeroed = 3*node - 1;
302 }
303}
304
305template<unsigned DIM>
307{
308 assert(mpExtendedBidomainTissue!=NULL);
309 return mpExtendedBidomainTissue;
310}
311
312template<unsigned DIM>
314{
316 {
317 std::cout << "Solved to time " << time << "\n" << std::flush;
318 }
319
320 double V_max_first_cell, V_min_first_cell, V_max_second_cell, V_min_second_cell, phi_e_min, phi_e_max;
321
322 VecStrideMax( this->mSolution, 0, CHASTE_PETSC_NULLPTR, &V_max_first_cell );
323 VecStrideMin( this->mSolution, 0, CHASTE_PETSC_NULLPTR, &V_min_first_cell );
324
325 VecStrideMax( this->mSolution, 1, CHASTE_PETSC_NULLPTR, &V_max_second_cell );
326 VecStrideMin( this->mSolution, 1, CHASTE_PETSC_NULLPTR, &V_min_second_cell );
327
328 VecStrideMax( this->mSolution, 2, CHASTE_PETSC_NULLPTR, &phi_e_max );
329 VecStrideMin( this->mSolution, 2, CHASTE_PETSC_NULLPTR, &phi_e_min );
330
332 {
333 std::cout << " V first cell = " << "[" <<V_min_first_cell << ", " << V_max_first_cell << "]" << ";\n"
334 << " V second cell = " << "[" <<V_min_second_cell << ", " << V_max_second_cell << "]" << ";\n"
335 << " Phi_e = " << "[" <<phi_e_min << ", " << phi_e_max << "]" << ";\n"
336 << std::flush;
337 }
338}
339
340template<unsigned DIM>
342{
343 if (!extending)
344 {
345 if (this->mNodesToOutput.empty())
346 {
347 // Set writer to output all nodes
348 this->mpWriter->DefineFixedDimension(this->mpMesh->GetNumNodes());
349 }
350// else
351// {
352// // Output only the nodes indicted
353// this->mpWriter->DefineFixedDimension( this->mNodesToOutput, this->mpMesh->GetNumNodes() );
354// }
355 //mNodeColumnId = mpWriter->DefineVariable("Node", "dimensionless");
356 mVoltageColumnId_Vm1 = this->mpWriter->DefineVariable("V","mV");
357 mVoltageColumnId_Vm2 = this->mpWriter->DefineVariable("V_2","mV");
358 mVoltageColumnId_Phie = this->mpWriter->DefineVariable("Phi_e","mV");
359 mVariablesIDs.push_back(mVoltageColumnId_Vm1);
360 mVariablesIDs.push_back(mVoltageColumnId_Vm2);
361 mVariablesIDs.push_back(mVoltageColumnId_Phie);
362
363 // Only used to get an estimate of the # of timesteps below (copied from Abstract class)
365 HeartConfig::Instance()->GetSimulationDuration(),
366 HeartConfig::Instance()->GetPrintingTimeStep());
367 this->mpWriter->DefineUnlimitedDimension("Time", "msecs", stepper.EstimateTimeSteps()+1); // +1 for start and end
368 }
369 else
370 {
371 mVoltageColumnId_Vm1 = this->mpWriter->GetVariableByName("V");
372 mVoltageColumnId_Vm2 = this->mpWriter->GetVariableByName("V_2");
373 mVoltageColumnId_Phie = this->mpWriter->GetVariableByName("Phi_e");
374 }
375 //define any extra variable. NOTE: it must be in the first cell (not the second)
377
378}
379
380template<unsigned DIM>
382{
383 this->mpWriter->PutUnlimitedVariable(time);
384
385 // Create a striped vector
386 Vec ordered_voltages = this->mpMesh->GetDistributedVectorFactory()->CreateVec(3);
387 DistributedVector wrapped_ordered_solution = this->mpMesh->GetDistributedVectorFactory()->CreateDistributedVector(ordered_voltages);
388 DistributedVector wrapped_solution = this->mpMesh->GetDistributedVectorFactory()->CreateDistributedVector(voltageVec);
389
390 DistributedVector::Stripe V_first_cell_stripe(wrapped_solution,0);
391 DistributedVector::Stripe V_second_cell_stripe(wrapped_solution,1);
392 DistributedVector::Stripe phi_e_stripe(wrapped_solution,2);
393
394 DistributedVector::Stripe wrapped_ordered_solution_first_stripe(wrapped_ordered_solution,0);
395 DistributedVector::Stripe wrapped_ordered_solution_second_stripe(wrapped_ordered_solution,1);
396 DistributedVector::Stripe wrapped_ordered_solution_third_stripe(wrapped_ordered_solution,2);
397
398 for (DistributedVector::Iterator index = wrapped_solution.Begin();
399 index != wrapped_solution.End();
400 ++index)
401 {
402 wrapped_ordered_solution_first_stripe[index] = V_first_cell_stripe[index];
403 wrapped_ordered_solution_second_stripe[index] = V_second_cell_stripe[index];
404 wrapped_ordered_solution_third_stripe[index] = phi_e_stripe[index];
405 }
406 wrapped_solution.Restore();
407 wrapped_ordered_solution.Restore();
408
409 this->mpWriter->PutStripedVector(mVariablesIDs, ordered_voltages);
410 PetscTools::Destroy(ordered_voltages);
411 //write any extra variable. Note that this method in the parent class will
412 //take the extra variable only from the first cell.
415}
416
417template<unsigned DIM>
419{
421 if (mFixedExtracellularPotentialNodes.empty())
422 {
423 // We're not pinning any nodes.
424 if (mRowForAverageOfPhiZeroed==INT_MAX)
425 {
426 // We're not using the constrain Average phi_e to 0 method, hence use a null space
427 // Check that the KSP solver isn't going to do anything stupid:
428 // phi_e is not bounded, so it'd be wrong to use a relative tolerance
429 if (HeartConfig::Instance()->GetUseRelativeTolerance())
430 {
431 EXCEPTION("Bidomain external voltage is not bounded in this simulation - use KSP *absolute* tolerance");
432 }
433 }
434 }
435}
436
437template<unsigned DIM>
439{
440 return mHasBath;
441}
442
443template<unsigned DIM>
445{
446 mHasBath = hasBath;
447}
448
449// Explicit instantiation
450template class ExtendedBidomainProblem<1>;
451template class ExtendedBidomainProblem<2>;
452template class ExtendedBidomainProblem<3>;
453
454// Serialization for Boost >= 1.36
#define EXCEPTION(message)
#define CHASTE_PETSC_NULLPTR
A macro to define PETSc null pointer based on the PETSc version.
#define EXPORT_TEMPLATE_CLASS_SAME_DIMS(CLASS)
void DefineExtraVariablesWriterColumns(bool extending)
DistributedVector CreateDistributedVector(Vec vec, bool readOnly=false)
void SetFixedExtracellularPotentialNodes(std::vector< unsigned > nodes)
virtual void DefineWriterColumns(bool extending)
void SetGgapHeterogeneities(std::vector< boost::shared_ptr< AbstractChasteRegion< DIM > > > &rGgapHeterogeneityRegions, std::vector< double > &rGgapValues)
void SetExtendedBidomainParameters(double Am1, double Am2, double AmGap, double Cm1, double Cm2, double Ggap)
void SetNodeForAverageOfPhiZeroed(unsigned node)
void SetIntracellularConductivitiesForSecondCell(c_vector< double, DIM > conductivities)
virtual AbstractCardiacTissue< DIM > * CreateCardiacTissue()
virtual void WriteOneStep(double time, Vec voltageVec)
void SetExtracellularStimulusFactory(AbstractStimulusFactory< DIM > *pFactory)
ExtendedBidomainTissue< DIM > * GetExtendedBidomainTissue()
virtual AbstractDynamicLinearPdeSolver< DIM, DIM, 3 > * CreateSolver()
std::vector< unsigned > mFixedExtracellularPotentialNodes
void GetIntracellularConductivities(c_vector< double, 3 > &rIntraConductivities) const
static HeartConfig * Instance()
static void Destroy(Vec &rVec)
static bool AmMaster()
static void Barrier(const std::string callerId="")
unsigned EstimateTimeSteps() const